Paper Detail
Sina Wendrich, Lukas Förner, Zoe Reinke, Kartikay Tehlan, Ansgar Berlis, Michael Frühwald, Matthias Wagner, Thomas Wendler
Longitudinal multiparametric MRI is central to follow-up imaging in oncology, yet real-world clinical data are characterised by missing sequences, heterogeneous acquisition protocols, and varying spatial resolutions across time points. We propose a patient-specific conditional implicit neural representation (INR) that models multimodal longitudinal MRI as a continuous function of world coordinates, time, and modality conditioning. The model is trained with stochastic modality dropout to handle incomplete data, and its continuous coordinate-space formulation enables both spatial and temporal interpolation without resampling to a fixed voxel grid. A self-consistency-based confidence estimator is derived from cross-modal reconstruction performance at inference time. We evaluate the framework on longitudinal MRI from paediatric brain tumour patients, demonstrating statistically significant improvements over linear interpolation for T1CE and FLAIR (p < 0.05), with mean MS-SSIM of 0.95 $\pm$ 0.02 for T1CE. Predicted confidence correlates strongly with true reconstruction quality (Pearson r up to 0.996), suggesting reliable deployment potential in heterogeneous clinical settings.
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@article{wendrich2026implicit,
title = {Implicit Neural Representations for Multimodal Longitudinal Image Imputation and Interpolation},
author = {Sina Wendrich and Lukas Förner and Zoe Reinke and Kartikay Tehlan and Ansgar Berlis and Michael Frühwald and Matthias Wagner and Thomas Wendler},
year = {2026},
abstract = {Longitudinal multiparametric MRI is central to follow-up imaging in oncology, yet real-world clinical data are characterised by missing sequences, heterogeneous acquisition protocols, and varying spatial resolutions across time points. We propose a patient-specific conditional implicit neural representation (INR) that models multimodal longitudinal MRI as a continuous function of world coordinates, time, and modality conditioning. The model is trained with stochastic modality dropout to handle i},
url = {https://arxiv.org/abs/2608.02324},
keywords = {cs.CV},
eprint = {2608.02324},
archiveprefix = {arXiv},
}
{}