Paper Detail
Mariano Barone, Francesco Di Serio, Roberto Moio, Marco Postiglione, Giuseppe Riccio, Antonio Romano, Vincenzo Moscato
Large Language Models (LLMs) are increasingly deployed in healthcare, yet their communicative alignment with clinical standards remains insufficiently quantified. We conduct a multidimensional evaluation of general-purpose and domain-specialized LLMs across structured medical explanations and real-world physician-patient interactions, analyzing semantic fidelity, readability, and affective resonance. Baseline models amplify affective polarity relative to physicians (Very Negative: 43.14-45.10% vs. 37.25%) and, in larger architectures such as GPT-5 and Claude, produce substantially higher linguistic complexity (FKGL up to 16.91-17.60 vs. 11.47-12.50 in physician-authored responses). Empathy-oriented prompting reduces extreme negativity and lowers grade-level complexity (up to -6.87 FKGL points for GPT-5) but does not significantly increase semantic fidelity. Collaborative rewriting yields the strongest overall alignment. Rephrase configurations achieve the highest semantic similarity to physician answers (up to mean = 0.93) while consistently improving readability and reducing affective extremity. Dual stakeholder evaluation shows that no model surpasses physicians on epistemic criteria, whereas patients consistently prefer rewritten variants for clarity and emotional tone. These findings suggest that LLMs function most effectively as collaborative communication enhancers rather than replacements for clinical expertise.
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@article{barone2026can,
title = {Can "AI" Be a Doctor? A Study of Empathy, Readability, and Alignment in Clinical LLMs},
author = {Mariano Barone and Francesco Di Serio and Roberto Moio and Marco Postiglione and Giuseppe Riccio and Antonio Romano and Vincenzo Moscato},
year = {2026},
abstract = {Large Language Models (LLMs) are increasingly deployed in healthcare, yet their communicative alignment with clinical standards remains insufficiently quantified. We conduct a multidimensional evaluation of general-purpose and domain-specialized LLMs across structured medical explanations and real-world physician-patient interactions, analyzing semantic fidelity, readability, and affective resonance. Baseline models amplify affective polarity relative to physicians (Very Negative: 43.14-45.10\% v},
url = {https://arxiv.org/abs/2604.20791},
keywords = {cs.CL, cs.AI},
eprint = {2604.20791},
archiveprefix = {arXiv},
}
{}