Paper Detail

Beyond the Basics: Leveraging Large Language Model for Fine-Grained Medical Entity Recognition

Nwe Ni Win, Jim Basilakis, Steven Thomas, Seyhan Yazar, Laura Pierce, Stephanie Liu, Paul M. Middleton, Nasser Ghadiri, X. Rosalind Wang

arxiv Score 7.3

Published 2026-04-19 · First seen 2026-04-21

General AI

Abstract

Extracting clinically relevant information from unstructured medical narratives such as admission notes, discharge summaries, and emergency case histories remains a challenge in clinical natural language processing (NLP). Medical Entity Recognition (MER) identifies meaningful concepts embedded in these records. Recent advancements in large language models (LLMs) have shown competitive MER performance; however, evaluations often focus on general entity types, offering limited utility for real-world clinical needs requiring finer-grained extraction. To address this gap, we rigorously evaluated the open-source LLaMA3 model for fine-grained medical entity recognition across 18 clinically detailed categories. To optimize performance, we employed three learning paradigms: zero-shot, few-shot, and fine-tuning with Low-Rank Adaptation (LoRA). To further enhance few-shot learning, we introduced two example selection methods based on token- and sentence-level embedding similarity, utilizing a pre-trained BioBERT model. Unlike prior work assessing zero-shot and few-shot performance on proprietary models (e.g., GPT-4) or fine-tuning different architectures, we ensured methodological consistency by applying all strategies to a unified LLaMA3 backbone, enabling fair comparison across learning settings. Our results showed that fine-tuned LLaMA3 surpasses zero-shot and few-shot approaches by 63.11% and 35.63%, respectivel respectively, achieving an F1 score of 81.24% in granular medical entity extraction.

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BibTeX

@article{win2026beyond,
  title = {Beyond the Basics: Leveraging Large Language Model for Fine-Grained Medical Entity Recognition},
  author = {Nwe Ni Win and Jim Basilakis and Steven Thomas and Seyhan Yazar and Laura Pierce and Stephanie Liu and Paul M. Middleton and Nasser Ghadiri and X. Rosalind Wang},
  year = {2026},
  abstract = {Extracting clinically relevant information from unstructured medical narratives such as admission notes, discharge summaries, and emergency case histories remains a challenge in clinical natural language processing (NLP). Medical Entity Recognition (MER) identifies meaningful concepts embedded in these records. Recent advancements in large language models (LLMs) have shown competitive MER performance; however, evaluations often focus on general entity types, offering limited utility for real-wor},
  url = {https://arxiv.org/abs/2604.17214},
  keywords = {cs.AI},
  eprint = {2604.17214},
  archiveprefix = {arXiv},
}

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